MTHFR and Infertility

The amount of blood draws that occur with infertility is astonishing. Chances are you have had genetic testing done or heard of the MTHFR gene mutation that more than 40 percent of us carry. When looking at your supplements and lifestyle for infertility, this gene matters most commonly when deciding between taking folic acid or folate. Folate (vitamin B9) is naturally occurring, and folic acid is synthetic.

There are two common gene variants of the MTHFR gene, C677T and A1298C. If you or your partner have two C677T variants of a gene or a C677T and an A1298C variant, you will have a positive for elevated homocysteine levels. When this gene is not doing its job, it will not convert homocysteine to methionine, thus you will have elevated homocysteine levels. In turn, you will not metabolize folic acid to folate, leading to a deficiency in folate.

What Happens When You Consume Folic Acid with the MTHFR Gene Mutation?

If you take folic acid and you have the MTHFR genetic mutation, will form buildup and cause an inability to detoxify properly. This can lead to health problems, including decrease metabolization of vitamin B12. Additional research is needed however, recurrent miscarriages, neural tube defects, preeclampsia, intrauterine growth restriction, and premature births are thought to be associated with MTHFR variants.

How Does The MTHFR Gene Affect Infertility

One study took 30 couples that had fertility complications, including miscarriage and failed IVF treatments. One of the individuals was known to have the MTHFR gene defect. They placed both the man and woman on 800 mcg daily of folate supplement for four months. In the end, 27 of them conceived!

Food Supplements to Increase Your Daily Folate Intake

Eating foods such as leafy greens, asparagus, avocados, brussel sprouts, and leafy greens will increase folate. Eggs, nuts, beans will increase your intake of B12. Talk to me about home testings that are cost-effective and efficient in determining if you carry the MTHFR gene and what changes you can make with those results!

*This blog and website provide general health information for educational purposes only. The information on this website, in literature, and in presentations are not to be used as a substitute for medical advice, cannot diagnose or treat any health condition, and do not substitute for care from your own physician.