Thousands of couples struggle with unexplained infertility and a failed fertility treatment cycle is disheartening. For those who choose to move forward with additional treatments, the approach is highly individualized and takes many factors into consideration. When it comes to treatment options, it’s vital to know the statistics of your treatment so that as you move forward, you are well informed and confident with your decisions.

Research can get sticky and confusing as many things are taken into consideration, such as patient, age, drugs utilized for treatment, and clinic statistics. For this particular blog, we will look at statistics for live births per cycle for women under the age of 38 with the diagnosis of unexplained infertility. When we talk about unexplained infertility, commonly this means the woman has good egg count, fallopian tubes are clear, the uterus has no concerns, sperm count has been determined to be within normal parameters, and no other explanation for the inability to conceive.

What If Multiple Rounds of IUI Have Failed?

My coaching tip is consider a re-group with your medical provider after failing 3-4 rounds of IUI to discuss what your options are moving forward and any changes that could be implemented. Of course, always keeping in mind the statistics of each new treatment being considered. When I was going through IUI’s, I had a second opinion and was informed that the success rate after three rounds was 3 percent. Knowing our financial situation, we decided to move on to IVF. This decision is very personal but should consider the financial, emotional, and physical factors of your situation.

Here are 5 statistics that may surprise you and could impact your plan of action:

1. After three medicated IUI cycles with Letrozole or Clomid, success rates can range from 15-25 percent.
2. No medication, 1-6 percent live birth rate per cycle
3. Letrozole, 9.6 percent live birth rate per cycle
4. Clomid, 9.4 percent live birth rate per cycle
5. Gonadotropins (injectables), 11.6 percent live birth rate per cycle

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